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Ixabiso eliphantsi leNitroimidazoleCAS: 527-73-1

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Ixabiso eliphantsi leNitroimidazoleCAS: 527-73-1

Uphakathi lweMisonidazole, i-oncology radiosensitizer, isetyenziswa njenge-organic synthesis intermediate.
Isetyenziselwa ukulungiselela i-nitroimidazole-substituted boric acid njenge-precursor ye-hypoxic tissue imaging. Ikwasetyenziselwa ukulungiselela ii-radiosensitizers ezikhethiweyo zesiza samathumba atyebileyo kwii-estrogen receptors.


Iinkcukacha Product

Iimpawu zemveliso

Intshayelelo yeMveliso

Igama lesiNgesi: 2-Nitroimidazole
I-CAS: 527-73-1
Amagama: 11a; amicin; AZOMYCIN; ro05-9129; AZOMYCINE; 2-NITROMIDAZOLE; 2-nitro-imidazo; 2-Nitroimidaxole; WLN: T5M CNJ BNW; 2-NITROIMIDAZOLE
Indawo yokunyibilika: 287 ° C (umhla) (ivuliwe)
Indawo yokubilisa: 211.75 ° C
Ubunzima: 1.5988
Isalathiso sokubonisa: 1.4264
Iimeko zokugcina: Ukukhenkcisa
Ukunyibilika: I-NH4OH: i-soluble50mg / mL, icacile, ityorororor

Inkangeleko

I-PKA: 8.72 ± 0.10 (eqikelelwe)
Umbala: Lightyellowtokhaki - luhlaza
Iipropathi zeKhemikhali: Ikhristal ekhanyayo emthubi. Indawo yokunyibilika 283 ℃ (ukubola). I-Soluble kwi-methanol, i-ethanol, i-acetone, i-ethyl acetate, inganyibiliki kwi-ether, chloroform

Sebenzisa:

Uphakathi lweMisonidazole, i-oncology radiosensitizer, isetyenziswa njenge-organic synthesis intermediate.
Isetyenziselwa ukulungiselela i-nitroimidazole-substituted boric acid njenge-precursor ye-hypoxic tissue imaging. Ikwasetyenziselwa ukulungiselela ii-radiosensitizers ezikhethiweyo zesiza samathumba atyebileyo kwii-estrogen receptors.

Faka isicelo

I-Nitroimidazole (2-nitroimidazole) yinto esisiseko eluhlaza yokwenziwa kunye nokuveliswa kweemichiza ze-nitroimidazole kwii-radiosensitizers ze-electronophilic. Iziphumo ezivela endaweni ye-N ezilungiselelwe ukusuka kwi-2-nitroimidazole zisetyenzisiwe njenge-anti-tumor radiosensitizers kwizifundo zeklinikhi. 2. I-nitroimidazole esekwe kwiChemicalbook ibaluleke kakhulu phakathi kweentlobo ngeentlobo zezichukumisi zeradiotherapy zamathumba, ezinje ngeMisonidazole, pimonidazole, etanidazole, njl.
Imvelaphi: Ithumba elibi sisifo esiqhelekileyo esisongela ubomi bomntu. Malunga nama-70 ukuya kuma-80 eepesenti ala mathumba afuna unyango lwemitha. Iiradiosensitizers zitsale umdla omkhulu kwiradiotherapy ngenxa yesakhono sazo sokwandisa ubuntununtunu beeseli zethumba kwimitha. I-2-nitroimidazole ibalulekile phakathi kweentlobo ngeentlobo zezichukumisi zeradiotherapy zomhlaza, ezinje ngeMisonidazole, pimonidazole, etanidazole, njlnjl. 2-nitroimidazole.

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